Lagrand, et al.
Journal of Wound Care, Vol. 32, No.4 (2023)
20 Patients with long lasting diabetic foot ulcers were treated 10 times during a period of 2 weeks. Primary outcome parameter was the occurrence of serious side effects of the cold plasma treatment. Secondary outcome parameters were wound healing and number of bacteria.
Remarkable results with PLASOMA: wound healing and reduction in number of bacteria
More than half of the wounds reduced >50% in size during the two weeks of treatment, two wounds (10%) healed completely during this treatment period. The number of Staphylococcus aureus bacteria decreased significantly directly after cold plasma treatment. That is important because S. aureus is seen as one of the most important pathogens in diabetic foot infections. No serious side effects occurred; all side effects were mild and temporary.
This study demonstrates that this cold plasma treatment in diabetic foot ulcers is safe and well tolerated.
This clinical trial on safety has been performed at the Amsterdam UMC. The principle investigator was Dr. Edgar Peters, the other investigators were Dr. Louise Sabelis and Dr. Rimke Lagrand.
